Potency matters: Thresholds govern endocrine activity
نویسندگان
چکیده
منابع مشابه
TLRs govern neutrophil activity in aspergillosis.
Polymorphonuclear neutrophils (PMNs) are essential in initiation and execution of the acute inflammatory response and subsequent resolution of fungal infection. PMNs, however, may act as double-edged swords, as the excessive release of oxidants and proteases may be responsible for injury to organs and fungal sepsis. To identify regulatory mechanisms that may balance PMN-dependent protection and...
متن کاملSignaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of nave CD8 T cells
Variable sensitivity to T-cell-receptor (TCR)and IL-7-receptor (IL-7R)-mediated homeostatic signals among naı̈ve T cells has thus far been largely attributed to differences in TCR specificity. We show here that even when withdrawn from self-peptideinduced TCR stimulation, CD8+ T cells exhibit heterogeneous responses to interleukin-7 (IL-7) that are mechanistically associated with IL-7R expressio...
متن کاملKnowledge matters: Institutional Frameworks to Govern the Provision of Global Public Goods
The provision of Global Public Goods (GPG) 1 has been extensively discussed in the recent literature. It has been the object of recent theoretical advances and has increasingly entered political debates both at the UN and at the EU levels. This paper focuses on the institutional frameworks relevant to make decision about the provision of these goods. This particular focus serves a double goal, ...
متن کاملSignaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells
Variable sensitivity to T-cell-receptor (TCR)- and IL-7-receptor (IL-7R)-mediated homeostatic signals among naïve T cells has thus far been largely attributed to differences in TCR specificity. We show here that even when withdrawn from self-peptide-induced TCR stimulation, CD8(+) T cells exhibit heterogeneous responses to interleukin-7 (IL-7) that are mechanistically associated with IL-7R expr...
متن کاملPrinciples of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.
The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Regulatory Toxicology and Pharmacology
سال: 2013
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2013.06.007